Cysteamine hydrochloride

CAS No. 156-57-0

Cysteamine hydrochloride( 2-Mercaptoethylamine hydrochloride )

Catalog No. M12233 CAS No. 156-57-0

An agent for the treatment of nephropathic cystinosis and an antioxidant; increases intracellular glutathione levels in cystinotic cells, also increases the rates of apoptosis in cystinotic cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cysteamine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    An agent for the treatment of nephropathic cystinosis and an antioxidant; increases intracellular glutathione levels in cystinotic cells, also increases the rates of apoptosis in cystinotic cells.
  • Description
    An agent for the treatment of nephropathic cystinosis and an antioxidant; increases intracellular glutathione levels in cystinotic cells, also increases the rates of apoptosis in cystinotic cells; is an excellent scavenger of OH and HOCl and also reacts with H2O2; significantly increase the intracellular GSH levels; also causes autophagosome accumulation in cancer cells.Other Indication Approved(In Vitro):Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine hydrochloride administration. Cysteamine hydrochloride has antioxidant properties as a result of increasing glutathione production. Cysteamine hydrochloride is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine hydrochloride increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine hydrochloride exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine hydrochloride treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine hydrochloride to doxorubicin results in a dramatic increase in cell death.Cysteamine hydrochloride (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    2-Mercaptoethylamine hydrochloride
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    156-57-0
  • Formula Weight
    113.6096
  • Molecular Formula
    C2H8ClNS
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C(CS)N.Cl
  • Chemical Name
    Ethanethiol, 2-amino-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Besouw, M, et al. Drug Discov Today, 2013. 18(15-16): p. 785-92. 2. de Matos, D.G, et al. Mol Reprod Dev, 1995. 42(4): p. 432-6. 3. Wan XM, et al. Int J Cancer. 2011 Sep 1;129(5):1087-95.
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